2023
Teo YV, Hinthorn SJ, Webb AE, Neretti N. Single-cell transcriptomics of peripheral blood int he aging mouse. Aging. 2023 Jan 6; 15(1):6-20. View in Pubmed.

2022
Hajdarovic KH, Yu D, Webb AE. Understanding the aging hypothalamus, one cell at a time. Trends Neurosci, 2022. Dec; 45(12): 945-954.

Lakis NS, Brodsky AS, Karashchuk G, Audesse AJ, Yang D, Sturtevant A, Lombardo K, Wong IY, Webb AE, Anthony DC. Stem cell phenotype predicts therapeutic response in glioblastomas with MGMT promoter methylation. Acta Neuropathol Commun, 2022 Nov 4; 10(1): 159.

*Hajdarovic KH, *Yu D, Hassell L, Evans SA, Packer S, Neretti N, Webb AE. Single-cell analysis of the aging female mouse hypothalamus. Nature Aging, 2022. Jul 4; 2(7): 662-678. *Equal contribution.

2021
Audesse AJ, Karashchuk G, Gardell ZA, Lakis NS, Maybury-Lewis SY, Brown AK, Leeman DS, Teo YV, Neretti N, Anthony DC, Brodsky AS, Webb AE. FOXO3 regulates a common genomic program in aging and glioblastoma stem cells. Aging and Cancer. 2021 Dec 18:1-23.

Curley DE, Webb AE, Sheffler DJ, Haass-Koffler CL. Corticotropin releasing factor binding protein as a novel target to restore brain homeostasis: lessons learned from alcohol use disorder research. Front Behav Neurosci. 2021 Nov 29; 15:786855. View in PubMed.

Maybury-Lewis SY, Brown AK, Yeary M, Sloutskin A, Dhakal S, McCarthy-Sinclair B, Juven-Gershon T, Webb AE. Changing and stable chromatin accessibility supports transcriptional overhaul during neural stem cell activation and is altered with age. Aging Cell, 2021 Oct 23:313499. View in PubMed.

McCauley BS, Sun L, Yu R, Lee M, Liu H, Leeman DS, Huang Y, Webb AE, Dang W. Altered chromatin states drive cryptic transcription in aging mammalian stem cells. Nature Aging. 2021 Aug 2; (1): 684-697. View in PubMed.

Brown AK, Maybury-Lewis SY, Webb AE. Integrative multi-omics analysis reveals conserved hierarchical mechanisms of FOXO3 pioneer factor activity. View in bioRxiv.
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Hajdarovic KH, Yu D, Hassell L, Evans SA, Neretti N, Webb AE. Single cell analysis of the aging hypothalamus. View in bioRxiv.

Babcock KR, Page JS, Fallon JR, Webb AE. Adult hippocampal neurogenesis in aging and Alzheimer's disease. Stem Cell Rep. 2021 Feb 25. View in PubMed.

Teo YV, Webb AE, Neretti N, Single cell transcriptomics of peripheral blood in the aging mouse. View in bioRxiv.

2020
Audesse AJ and Webb AE. Mechanisms of enhanced quiescence in neural stem cell aging. Mech Ageing Dev. 2020 Aug8; 191:111323. View in PubMed. 

Vonk WIM, Rainbolt TK, Dolan PT, Webb AE, Brunet, Frydman J. Differentiation drives widespread rewiring of the neural stem cell chaperone network. Mol Cell. 2020 Mar 30. View in PubMed.

Maybury-Lewis SY and Webb AE. Taking prisoners: Vimentin cages capture proteasomes during NSC activation. Cell Stem Cell. 2020 Apr 2;26(4):473-475. View in PubMed.


2019
Audesse AJ, Dhakal S, Hassell L-A, Gardell Z, Nemstova Y, Webb AE. FOXO3 directly regulates an autophagy network to functionally regulate proteostasis in adult neural stem cells. Plos Genetics. 2019 Apr 11;15(4):e1008097. View in PubMed


2018
Schäffner I, Minakaki G, Khan MA, Balta EA, Schlötzer-Schrehardt U, Schwarz TJ, Beckervordersandforth R, Winner B, Webb AE, DePinho RA, Paik J, Wurst W, Klucken J, Lie DC. FoxO Function Is Essential for Maintenance of Autophagic Flux and Neuronal Morphogenesis in Adult Neurogenesis. Neuron. 2018 Sep 19;99(6):1188-1203. View in PubMed.

Audesse AJ, Webb AE. Enhancing lysosomal activation restores neural stem cell function during aging. J Exp Neurosci 2018 Aug 23: 12:1179069518795874. View in Pubmed.

Atkinson EG, Audesse AJ, Palacios JA, Bobo DM, Webb AE, Ramachandran S, Henn BM. No evidence for recent selection at FOXP2 among diverse human populations. Cell. 2018 Jul 27. pii: S0092-8674(18)30851-1. View in PubMed.

Leeman DS, Hebestreit K, Ruetz T, Webb AE, McKay A, Pollina EA, Dulken BW, Zhao X, Yoo R, Ho TT, Mahmoudi S, Devarajan K, Passegue E, Rando TA, Frydman J, Brunet A. Modulating the lysosome impacts protein aggregation in quiescent neural stem cells and ameliorates their ability to activate during aging. Science. 2018 Mar 16;359(6381):1277-1283. View in PubMed.

Brown AK and Webb AE. Regulation of FOXO factors in mammalian cells. Current Topics in Developmental Biology. 2018;127:165-192. View in PubMed.


2017
Kim SY and Webb AE. Neuronal functions of FOXO/DAF-16. Nutrition and Healthy Aging. 2017. Mar 31; 4(2): 113-126. View in PubMed.


2016
Ahlenius H, Chanda S, Webb AE, Yousif I, Karmazin J, Prusiner SB, Brunet A, Sudhof TC, Wernig M. Foxo3 regulates neuronal reprogramming of cells from postnatal and aging mice. PNAS. 2016. Jul 11. View in PubMed.

Webb AE, Kundaje AK, Brunet A. Characterization of the direct targets of FOXO transcription factors throughout evolution. Aging Cell. 2016; Aug;15(4):673-85. View in PubMed


2014
Webb AE, Brunet A. FOXO transcription factors: key regulators of cellular quality control. Trends in Biochemical Sciences. 2014; 39 (4) : 159-69. View in PubMed

Gopinath SD, Webb AE, Brunet A, Rando TA. FOXO3 promotes quiescence in adult muscle stem cells during the process of self-renewal. Stem Cell Reports. 2014; 2 (4) : 414-26. View in PubMed

Brunet A, Mahmoudi S, Mancini E, Rafalski VA and Webb AE. Longevity pathways in mammalian cells. 2014; 34. 


2013
Webb AE, Brunet A. FOXO flips the longevity SWItch. Nature Cell Biology. 2013; 15 (5) : 444-6. View in PubMed

Webb AE, Pollina EA, Vierbuchen T, Urbán N, Ucar D, Leeman DS, Martynoga B, Sewak M, Rando TA, Guillemot F, Wernig M, Brunet A. FOXO3 shares common targets with ASCL1 genome-wide and inhibits ASCL1-dependent neurogenesis. Cell Reports. 2013; 4 (3) : 477-91. View in PubMed

Wapinski OL, Vierbuchen T, Qu K, Lee QY, Chanda S, Fuentes DR, Giresi PG, Ng YH, Marro S, Neff NF, Drechsel D, Martynoga B, Castro DS, Webb AE, Südhof TC, Brunet A, Guillemot F, Chang HY, Wernig M.Hierarchical mechanisms for direct reprogramming of fibroblasts to neurons. Cell. 2013; 155 (3) : 621-35. View in PubMed


2012
Calnan DR, Webb AE, White JL, Stowe TR, Goswami T, Shi X, Espejo A, Bedford MT, Gozani O, Gygi SP, Brunet A. Methylation by Set9 modulates FoxO3 stability and transcriptional activity. Aging. 2012; 4 (7) : 462-79.


2011
Brett JO, Renault VM, Rafalski VA, Webb AE, Brunet A. The microRNA cluster miR-106b~25 regulates adult neural stem/progenitor cell proliferation and neuronal differentiation. Aging. 2011; 3 (2) : 108-24.


Prior to 2010
Renault VM, Rafalski VA, Morgan AA, Salih DA, Brett JO, Webb AE, Villeda SA, Thekkat PU, Guillerey C, Denko NC, Palmer TD, Butte AJ, Brunet A. FoxO3 regulates neural stem cell homeostasis. Cell Stem Cell. 2009; 5 (5) : 527-39. View in PubMed

Webb AE, Driever W, Kimelman D. psoriasis regulates epidermal development in zebrafish. Developmental Dynamics : an official publication of the American Association of Anatomists. 2008; 237 (4) : 1153-64. View in PubMed

Webb AE, Sanderford J, Frank D, Talbot WS, Driever W, Kimelman D. Laminin alpha5 is essential for the formation of the zebrafish fins. Developmental Biology. 2007; 311 (2) : 369-82. View in PubMed

Webb AE, Kimelman D. Analysis of early epidermal development in zebrafish. Methods in Molecular Biology (Clifton, N.J.). 2005; 289 : 137-46.

Pyati UJ, Webb AE, Kimelman D. Transgenic zebrafish reveal stage-specific roles for Bmp signaling in ventral and posterior mesoderm development. Development (Cambridge, England). 2005; 132 (10) : 2333-43. View in PubMed

Lemieux J, Lakowski B, Webb A, Meng Y, Ubach A, Bussière F, Barnes T, Hekimi S. Regulation of physiological rates in Caenorhabditis elegans by a tRNA-modifying enzyme in the mitochondria. Genetics. 2001; 159 (1) : 147-57.